脂肪组织中的脂肪调动是由脂肪甘油三酸脂酶促进的
Robert Zimmermann1, Juliane G Strauss, Guenter Haemmerle
1Institute of Molecular Biosciences, University of Graz, Graz, Austria.
概括
一种新发现的酶,脂肪甘油三酸脂酶 (ATGL),对于分解脂肪组织中储存的脂肪至关重要. ATGL 与激素敏感脂酶 (HSL) 合作,管理能量和脂肪代谢.
科学领域:
- 生物化学 生物化学
- 代谢研究的研究.
- 脂质代谢 脂质的代谢
背景情况:
- 脂解,即储存的甘油三的分解,对于能量恒温是必不可少的.
- 功能失调的脂解与肥胖和胰岛素抵抗有关.
- 激素敏感脂酶 (HSL) 以前被认为是唯一负责哺乳动物脂肪组织中甘油三液解的酶.
研究的目的:
- 为了识别和描述参与脂肪组织中甘油三化物水解的新型酶.
- 为了研究脂肪三糖 lipase (ATGL) 在脂解过程中的作用.
主要方法:
- 酶活性检测试验对酶活性进行检测.
- 在小鼠和人类脂肪组织中进行基因表达分析.
- 基质特异性研究研究
- 抑制研究 抑制研究
主要成果:
- 脂肪甘油三酸脂酶 (ATGL) 被确定为催化甘油三酸水解的初始步骤的关键酶.
- ATGL 含有一种帕塔丁域,这种域是植物乙烯基水解酶的特征.
- 在脂肪组织中ATGL的表达很高,并且对三糖醇具有很高的基质特异性.
- 抑制ATGL显著降低了整体脂肪酸酶活性.
结论:
- ATGL是第二个主要酶,与HSL一起,参与哺乳动物脂肪组织中的甘油三代谢.
- 在协调的脂解途径中,ATGL起着至关重要的作用,影响能量平衡.
- 发现ATGL为调节脂肪代谢提供了新的见解,并为代谢障碍提供了潜在的治疗点.
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