减少左心室顺应在人类的 mitra 狭窄. 可逆内部约束的作用
1Department of Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Md.
Circulation
|April 1, 1992
概括
中心静脉狭窄通过降低左心室顺应,而不是静脉功能,损害了透缩功能. 气球膜整形有效地扭转了在关狭窄症患者的腹痛功能障碍.
科学领域:
- 心脏病学 心脏病学
- 心血管生理学心血管生理学
背景情况:
- 影响左心室 (LV) 性能的中枢狭窄症 (MS) 机制尚不清楚.
- 减少MS填充影响血液动力学测量,使分析复杂化.
研究的目的:
- 为了研究人关节狭窄的压力-体积关系.
- 为了比较MS患者和健康对照者的LV性能.
主要方法:
- 使用导电导管导管/微文仪技术,暂时阻塞下静脉腔.
- 在9名多发性硬化患者和8名年龄匹配对照中生成压力-体积关系.
- 在一小部分患者中评估气球膜整形术的影响.
主要成果:
- 与对照组相比,多发性硬化症患者的心脏输出量和终端透析体积减少.
- 在MS患者和对照人群中,缩功能是可比的.
- 多发性硬化症患者表现出腹功能受损,腹压力-体积关系向左偏移,并且更, (遵守性较低).
结论:
- 额头管狭窄会损害透缩功能,其特点是减少LV遵守.
- 气球膜整形急性地逆转了这种扩张性损伤,在随访时具有持续的影响.
- 降低 LV 合规性可能是由于心室连接到异常的中枢装置的功能限制.
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