心脏潜力和潜在梯度场由单个,联合和连续的冲击在心室除过程中产生的心脏潜力和潜在梯度场
J M Wharton1, P D Wolf, W M Smith
1Department of Medicine, Duke University Medical Center, Durham, N.C. 27710.
Circulation
|April 1, 1992
概括
了解除冲击的有效性需要分析潜在的梯度场. 这项研究表明,虽然最小梯度是一致的,但不均的场所可能导致除失败或失律,影响除门电流.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 电子生理学 电子生理学
背景情况:
- 确定潜在梯度场对于理解除冲击效应至关重要.
- 缺乏使用各种电极配置进行除的既定要求.
研究的目的:
- 评估潜在的梯度场对除的要求.
- 评估不同电极配置对除功效的影响.
主要方法:
- 在12只开放胸部的狗中使用74个心上电极记录了电位场,在除冲击期间.
- 测试了四种电极配置:R:V,L:V, (R+L):V,以及连续的R:V----L:V冲击.
- 测量的除门 (DFT) 电流和最小电位梯度.
主要成果:
- 顺序的R:V----L:V配置具有明显较低的DFT电流.
- 在DFT的最小电位梯度在各种配置中是相似的 (约. 6-7V/cm) 的情况.
- 潜在梯度场不均 (变化15-27倍),某些区域的场弱,与未成功冲击后的激活地点相关联.
结论:
- 来自小心上电极的除场非常不均.
- 在两个心室之间最小的潜在梯度对于除是必不可少的.
- 达到这种梯度所需的冲击强度的变化解释了配置之间的DFT差异.
- 高梯度区域可以诱导子宫外激活后冲击.
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