总合成中的螺旋二氧化物:环氧氨酸
Sreenivas Katukojvala1, Kristin N Barlett, Stephen D Lotesta
1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Journal of the American Chemical Society
|November 26, 2004
概括
这项研究介绍了用于总合成的螺旋二氧化物功能组,使其能够有效地通往蛋白酶体抑制剂epoxomicin的途径. 该方法产生了有价值的合成非替代和相关化合物.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 螺旋二氧化物功能组是有机合成中的一种新型动机.
- 蛋白酶体抑制剂是关键的治疗药物,而氧素就是一个强有力的例子.
研究的目的:
- 报告螺旋二氧化物功能组在总合成中的首次应用.
- 使用这一新型组,开发一种有效的蛋白酶体抑制剂epoxomicin的合成.
主要方法:
- 艾伦的氧化形成螺旋二氧化物.
- 随后的化学转化螺旋二氧化物产生多种功能化子.
主要成果:
- 证明了螺旋二氧化物在构建复杂分子架构中的实用性.
- 实现了高效的epoxomicin的总合成.
- 用硫胺,胺基或胺基替代物合成了各种合成非替代和衍生物,包括正极,氧化,亚酸环氧化物和氧.
结论:
- 螺旋二氧化物功能组是有机合成中的多功能构建块.
- 这种方法为访问复杂分子 (如epoxomicin) 提供了一种战略方法.
相关概念视频
Molecular Compounds: Formulas and Nomenclature
Molecular compounds or covalent compounds result when atoms share electrons to form covalent bonds. Since there is no electron transfer, molecular compounds do not contain ions; instead, they consist of discrete, neutral molecules.
Organic Compounds
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
Functional Groups
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
Functional Groups
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
What is Organic Chemistry?
Organic chemistry is the study of compounds of carbon called organic compounds. Organic compounds either originate from living organisms or are synthesized by chemists. A defining trait of these compounds is the presence of carbon as the principal element, which is bonded to other carbon atoms and other elements such as hydrogen, oxygen, nitrogen, and sulfur. The existence of a wide array of organic molecules is a consequence of carbon atoms’ ability to form up to four strong bonds to other...
Ions, Molecules, and Compounds
Ions - When an atom participates in a chemical reaction that results in the donation or acceptance of one or more electrons, the atom becomes positively or negatively charged. This frequently happens for most atoms to have a full valence shell. This can happen either by gaining electrons to fill a shell that is more than half-full or by giving away electrons to empty a shell that is less than half-full, thereby leaving the next smaller electron shell as the new, full valence shell. An atom with...


