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Updated: Jul 6, 2026

Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study
12:43

Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study

Published on: July 27, 2016

在化合物混合物中,一种一般技术来排列蛋白质 - 配体结合的亲缘关系,并确定异质与直接结合位点的竞争

D Allen Annis1, Naim Nazef, Cheng-Chi Chuang

  • 1NeoGenesis Pharmaceuticals Inc., 840 Memorial Drive, Cambridge, MA 02139, USA. aannis@neogenesis.com

Journal of the American Chemical Society
|November 26, 2004
PubMed
概括

我们开发了一种亲和性选择质谱法 (AS-MS) 方法来排列蛋白质-连接体结合亲和性,并根据结合位点对连接体进行分类. 这个工具通过有效地识别和优化用于疾病标的化合物,有助于药物发现.

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Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling09:35

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

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Protein-protein Interfaces

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Protein Complexes with Interchangeable Parts

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Enzyme-Linked Immunosorbent Assay

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