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Updated: May 13, 2026

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases
06:10

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases

Published on: December 23, 2013

人类的5' --> 3'外核酶Xrn2促进了在共同转录分离部位的转录终止

Steven West1, Natalia Gromak, Nick J Proudfoot

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Nature
|November 27, 2004
PubMed
概括

这项研究揭示了一种同转录裂变 (CoTC) 活性,与多元A信号一起作用,启动Xrn2外核酶的RNA降解. 这一过程导致RNA聚合酶II (Pol II) 解离和转录终结,支持鱼雷模型.

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