在慢性心力衰竭患者中,格林素对左心室功能,运动能力和肌肉衰竭的影响
Noritoshi Nagaya1, Junji Moriya, Yoshio Yasumura
1Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. nagayann@hsp.ncvc.go.jp
Circulation
|December 1, 2004
概括
格林林治疗改善了慢性心力衰竭患者的心脏功能,运动能力,并减少了慢性心力衰竭患者的肌肉损耗. 这种类激素在控制心力衰竭症状方面表现有前途.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 生理学 生理学 生理学
背景情况:
- 格林是一种类激素,具有不同的生理作用,包括生长激素释放,血管扩张和食欲刺激.
- 它对慢性心力衰竭 (CHF) 的心血管功能和缓解症的影响以前未被探索.
研究的目的:
- 为了研究格林素给药对左心室 (LV) 功能,运动能力和肌肉衰竭在患有心脏不全症的患者的影响.
主要方法:
- 10名CHF患者接受了静脉注射格林 (2微克/公斤每天两次) 3周.
- 评估包括心声学,心肺运动测试,双X射线吸收计和治疗前后的血液采样.
- 一个由8名CHF患者组成的对照组没有接受格林.
主要成果:
- 格林林的使用显著降低了血中诺上腺素水平,增加了LV射出分数,LV质量,并减少了LV末缩体积.
- 运动能力改善,峰值工作量增加和氧气消耗增加.
- 肌肉消耗是逆转的,由增加的肌肉力量和瘦肉体质量证明.
结论:
- 在CHF患者中,重复施用格林显示了LV功能,运动能力和肌肉衰竭的显著改善.
- 这些发现表明格林素是治疗慢性心力衰竭的潜在治疗剂.
相关概念视频
Pathophysiology of Heart Failure
4.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Heart Failure II: Pathophysiology
1.9K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Heart Failure III: Clinical Manifestations
1.2K
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
1.2K
Heart Failure V: Medical Management
626
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
626
Heart Failure VI: Adjunct Therapies
632
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
632
Heart Failure VII: Nursing Interventions
787
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
787


