在弗雷明汉姆后代研究中,手臂动脉血管扩张功能和全身炎症
Joseph A Vita1, John F Keaney, Martin G Larson
1Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Mass, USA. jvita@bu.edu
Circulation
|December 1, 2004
概括
炎症会损害血管内皮功能,特别是在前臂微血管中,即使考虑到传统的危险因素. 这表明系统性炎症在血管运动功能障碍中起作用.
科学领域:
- 心血管科学 心血管科学
- 血管生物学 血管生物学
- 炎症研究 炎症研究
背景情况:
- 传统的危险因素和炎症会破坏血管内皮的功能,促进动脉样硬化.
- 内皮功能障碍涉及白细胞粘附度增加和氧化生物可用性降低.
- 风险因素,炎症和氧化之间的相互作用仍然不清楚.
研究的目的:
- 为了研究炎症会损害人类内皮功能的假设.
- 评估炎症标志物和内皮功能指标之间的关系.
主要方法:
- 评估了2701名弗雷明汉研究参与者 (平均年龄61岁).
- 测量了手臂动脉流介导扩张和反应性高血压.
- 评估了血清中C-反应蛋白 (CRP),互白素-6 (IL-6),可溶性细胞间粘附分子-1 (sICAM-1) 和单细胞化疗蛋白-1 (MCP-1) 的水平.
主要成果:
- 流介导扩张显示与CRP,IL-6和sICAM-1的反相关性,在调整风险因素后变得无意义.
- 反应性高血症与炎症标志物呈反相关性,因风险因素调整而减弱.
- 对CRP,IL-6和sICAM-1与反应性高血压的部分相关性仍然显著.
结论:
- 这些发现支持了风险因素诱导炎症,损害血管功能的假设.
- 除了传统的风险因素之外,炎症对流量介导扩张没有显示额外的影响.
- 由CRP,IL-6和sICAM-1表示的全身炎症可能导致前臂微血管血管功能受损.
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