吃饭后的高甘油三血症会增加内皮细胞微粒的循环水平
Alexandre C Ferreira1, Arley A Peter, Armando J Mendez
1University of Miami School of Medicine, Cardiovascular Center, Miami, Fla, USA. aferreir@med.miami.edu
在健康人群中,高脂肪饮食显著增加了内皮微粒 (EMP) 和甘油三. 脑电图可能表明从食后脂蛋白产生的内皮功能障碍.
科学领域:
- 心血管研究研究心血管研究
- 内皮功能研究 研究内皮功能研究.
背景情况:
- 内皮微粒 (EMP) 是内皮干扰的敏感指标.
- 饭后的脂质水平可能会影响血管健康.
研究的目的:
- 评估内皮微粒 (EMP) 水平与食后脂质变化之间的关系.
- 为了研究高脂肪饮食对健康志愿者的EMP的影响.
主要方法:
- 评估了18名健康受试者.
- 脂质和EMP水平在饭前和饭后1.3小时被测量.
- 试验对象食用的是低脂肪或高脂肪同热量食.
主要成果:
- 低脂肪饮食对EMP或脂质没有显著影响.
- 高脂饮食在饭后1个小时和3个小时显著增加了EMP水平 (P<0.0001).
- 增加的EMP水平与食后血清甘油三水平升高相关.
结论:
- 在健康个体中,单次高脂肪餐会提高血EMP水平.
- 升高的EMP与食后高甘油三血相关.
- EMPs可能作为由富含甘油三蛋白脂蛋白诱导的内皮功能障碍的标志物.
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