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在人类纯素核酸酸酶中促进振动. 一个分子动力学和混合量子力学/分子力学研究分子动力学和混合量子力学

Sara Núñez1, Dimitri Antoniou, Vern L Schramm

  • 1Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Journal of the American Chemical Society
|December 2, 2004
PubMed
概括

人类纯原核酸酶 (hPNP) 使用蛋白质促进的振动来稳定过渡状态. 氧原子的这种动态压缩通过增强电子密度和改善纯素环的离开组能力来加速酶催化.

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