混合痴呆症:新兴概念和治疗影响
Kenneth M Langa1, Norman L Foster, Eric B Larson
1Division of General Medicine, Department of Medicine, University of Michigan Medical School, Ann Arbor, USA. klanga@umich.edu
JAMA
|December 16, 2004
概括
混合痴呆症,结合阿尔茨海默病 (AD) 和血管痴呆症 (VaD),具有有限的药物效益. 管理心血管风险因素是预防和减缓进展的关键.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 药理学 药理学 是一个学科.
背景情况:
- 混合痴呆症,阿尔茨海默病 (AD) 和血管痴呆症 (VaD) 的同时发生,由于人口老龄化,越来越普遍.
- 了解AD和VaD之间的相互作用对于有效管理至关重要.
研究的目的:
- 审查混合痴呆症中AD和VaD的诊断,病理生理学和相互作用.
- 系统地审查混合痴呆症中药理疗法的证据.
主要方法:
- 搜索了"痴呆症"系统审查的柯克伦数据库.
- 搜索MEDLINE的英语文章 (过去10年) "混合痴呆"",阿尔茨海默病" + "脑血管疾病" + "药物治疗"和"血管痴呆" + "药物治疗".
主要成果:
- 混合性痴呆与衰老是常见的,经常显示与AD和血管病变共存.
- 药理疗法,包括胆酶抑制剂,在混合痴呆症中提供适度的益处,与AD治疗相比.
- 管理高血压等心血管风险因素是预防和减缓进展的有希望的策略.
结论:
- 目前的药物对已确定的混合痴呆症提供有限的临床益处.
- 控制心血管风险因素 (高血压,高脂血症) 和预防中风对于管理混合痴呆症至关重要.
- 需要进一步的研究来使治疗目标与患者和家庭的期望保持一致,并优化药物使用.
相关概念视频
Taste Buds and Receptors
5.6K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
5.6K
Psychosis: Goals of Pharmacotherapy
706
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
706
Alzheimer's Disease: Treatment
1.3K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.3K
Theoretical Approaches to Psychological Disorder
1.1K
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
1.1K
Positive Symptoms Schizophrenia: Hallucinations and Delusions
1.1K
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
1.1K
Drug Therapy
449
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
449


