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Smoothened的刺信号活动需要由蛋白激酶A和素激酶I进行酸化

Jianhang Jia1, Chao Tong, Bing Wang

  • 1Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. jin.jiang@utsouthwestern.edu

Nature
|December 24, 2004
PubMed
概括

蛋白激酶A (PKA) 和氨酸激酶I (CKI) 通过酸化光滑化 (Smo) 来调节刺 (Hh) 信号. 这种酸化控制了Smo细胞表面积累和动物发育过程中的通路活动.

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