不同多不和脂肪酸与男性冠状动脉病风险之间的相互作用
Dariush Mozaffarian1, Alberto Ascherio, Frank B Hu
1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA. dmozaffa@hsph.harvard.edu
Circulation
|January 5, 2005
概括
来自植物和海鲜来源的多不和脂肪酸 (PUFA) 与降低冠心病 (CHD) 风险有关. 较高的n-3PUFA摄入量,无论n-6PUFA水平如何,都对心血管健康有好处.
科学领域:
- 心血管营养 心血管营养
- 食中的脂肪酸 食中的脂肪酸
- 流行病学 流行病学
背景情况:
- 多不和脂肪酸 (PUFA) 的消费可能会降低冠状动脉疾病 (CHD) 的风险.
- 在n-6和n-3PUFA之间潜在的竞争可能会影响它们的收益.
- 关于心脏病风险的海鲜衍生的长链n-3PUFAs和植物衍生的中间链n-3PUFAs之间的相互作用尚未完全理解.
研究的目的:
- 调查不同类型的n-3多不和脂肪酸 (PUFA) 和冠心病 (CHD) 风险摄入之间的关联.
- 为了检查n-6PUFA摄入量是否会改变n-3PUFA摄入量与心脏病风险之间的关系.
主要方法:
- 一项前性队列研究,涉及45722名男性.
- 每4年通过经过验证的食物频率问卷评估的饮食摄入量.
- 冠心病 (CHD) 发病率,包括突然死亡和非致命的心肌梗塞,前性确定超过14年.
主要成果:
- 长链和中链n-3PUFA摄入量都与降低心脏病风险有关,独立于n-6PUFA摄入量.
- 较高的长链n-3PUFA摄入量与较低的突然死亡风险有关.
- 摄入中链n-3PUFA的较高摄入量与总心脏病风险的降低有关,特别是当长链n-3PUFA摄入量低时.
结论:
- n-3来自海鲜和植物来源的PUFA似乎可以降低心脏病风险.
- 背景:n-6PUFA摄入量不会显著改变n-3PUFA的心脏保护作用.
- 植物性n-3PUFAs可以显著降低心脏病风险,特别是在获取脂肪鱼的机会有限的人群中.
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