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Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
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预警NMR:一种快速而强大的实验方法,用于检测生化查中的反应性假阳性

Jeffrey R Huth1, Renaldo Mendoza, Edward T Olejniczak

  • 1Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA.

Journal of the American Chemical Society
|January 6, 2005
PubMed
概括

一种新的核磁共振 (NMR) 试验,ALARM NMR,在药物发现查中快速识别反应性假阳性. 这种方法可以检测出反应性杂质和分解产物,从而改善冲击分类,减少对不可活性的的浪费资源.

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Overview
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Nuclear Magnetic Resonance (NMR): Overview

Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
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NMR Spectrometers: Overview

NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
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Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
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Other Nuclides: 31P, 19F, 15N NMR

Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
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High-Performance Liquid Chromatography: Types of Detectors

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