尿道胎盘生长因子和孕前的风险
Richard J Levine1, Ravi Thadhani, Cong Qian
1Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, Md, USA.
JAMA
|January 6, 2005
概括
妊娠中期尿道胎盘生长因子 (PlGF) 的降低是预孕前发展的强有力的预测因素. 这一发现可能有助于早期发现这种妊娠并发症.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 孕前与血管性因素的不平衡有关,特别是高可溶性fms类铁酶1 (sFlt1) 和低胎盘生长因子 (PlGF).
- 尿液PlGF是一种潜在的生物标志物,因为它被脏过,与sFlt1.1.等较大的分子不同.
研究的目的:
- 为了调查是否减少的尿PlGF先于高血压和蛋白尿在孕前.
- 为了确定尿液中的PlGF水平是否可以预测孕前的发作.
主要方法:
- 一个嵌套的病例对照研究在预先怀孕预防试验中进行.
- 120对妇女 (孕前病例和正常压力对照) 根据地点,妊娠年龄和样本储存情况进行匹配.
- 测量了尿液中的plgf度,并将尿液中的肌素正常化.
主要成果:
- 尿液中的plgf水平在两组中都遵循了类似的模式,但在怀孕25-28周开始的孕前病例中显著降低.
- 在患有早发性子宫前症或分娩婴儿小于妊娠年龄的婴儿的情况下,观察到尿液PlGF显著减少.
- 在怀孕21-32周,尿液PlGF的最低四分位数 (<118 pg/mL) 与37周前孕前的风险增加了22.5倍.
结论:
- 在怀孕中期尿液PlGF的减少与随后的孕前的早期发展密切相关.
- 尿液PlGF可以作为一种有价值的预测生物标志物,用于早期检测孕前.
相关概念视频
01:33Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:24Gonadal and Placental Hormones
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
01:14Fetal Circulation
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...