同类氨酸和中风:证据表明孟德尔随机化的因果关系
Juan P Casas1, Leonelo E Bautista, Liam Smeeth
1Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, London WC1E 6 JJ, UK.
Lancet (London, England)
|January 18, 2005
概括
具有MTHFR T等位基因的个体具有更高的homocysteine水平,增加中风风险. 这项研究证实观察到的中风风险与预测一致,支持同类氨酸和中风之间的因果关系.
科学领域:
- 遗传学 是一个遗传学.
- 心血管流行病学心血管流行病学
- 生物化学 生物化学
背景情况:
- 在MTHFR C677T多态性影响同类氨酸水平.
- 具有TT基因型的个体具有更高的homocysteine度.
- 高水平的同类半氨酸是中风的潜在危险因素.
研究的目的:
- 为了研究TT同胞体中预测和观察到的中风风险之间的一致性.
- 评估MTHFR基因型,同类半氨酸水平和中风风险之间的因果关系.
主要方法:
- 进行了对MTHFR多态性和同类氨酸/中风研究的系统文献搜索.
- 进行了元分析来计算基因型-中风关联的聚合几率比率.
- 使用相互作用测试评估预期和观察到的中风风险之间的一致性.
主要成果:
- 对111项研究 (15,635人) 的分析发现,TT类同胞体比CC类同胞体高出1.93微摩尔/升.
- 在TT同胞体中,预测中风几率比为1.20 (1.10-1.31).
- 在TT同胞体中观察到的中风几率比为1.26 (1.14-1.40),与预测一致 (p=0.29).
结论:
- 在MTHFR TT同胞体中观察到的中风风险与基于homocysteine水平的预测密切匹配.
- 这一一致性支持同型半氨酸在中风病原性中的因果作用.
- 调查结果在不同的人口和地理位置之间是一致的.
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