慢性淋巴细胞炎症确定了子的器官热带性
Mathias Heikenwalder1, Nicolas Zeller, Harald Seeger
1Institute of Neuropathology, University Hospital of Zürich, CH-8091 Zürich, Switzerland.
概括
慢性炎症可以导致子在新器官中积累. 这通过淋巴毒素依赖的途径发生,可能增加病传播风险.
科学领域:
- 神经免疫学 神经免疫学
- 子生物学 子生物学
- 病变发生学研究 病变发生学研究
背景情况:
- 子 (错误折叠的蛋白质) 通常准神经和淋巴组织.
- 抗炎性细胞因子和免疫细胞对于淋巴细胞组织中的子复制至关重要.
研究的目的:
- 调查炎症状况是否影响非淋巴体器官的普里昂病原发生.
- 确定炎症在扩大质组织分布中的作用.
主要方法:
- 向患有诱导性炎症性脏,胰腺或肝脏疾病的小鼠注射子.
- 分析了子积累,淋巴毒素表达和炎症组织中FDC-M1+细胞的存在.
- 在缺少淋巴毒素α或其受体的小鼠中检查了子病原体.
主要成果:
- 慢性淋巴细胞炎症使以前无子的器官能够积累子.
- 炎症焦点显示了相关的淋巴毒素上调和宫外FDC-M1+细胞诱导.
- 缺乏淋巴毒素α或其受体的小鼠没有积累PrPSc或显示感染性.
结论:
- 慢性炎症状况可以扩大子的组织分布.
- 淋巴毒素信号传递对于炎症的非淋巴体器官中的子积累至关重要.
- 炎症可能会改变病的传播.
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