在基于脂的系统中,立方相和立方相分散
Markus Johnsson1, Justas Barauskas, Fredrik Tiberg
1Camurus AB, Ideon, Gamma 2, Sölvegatan 41, SE-223 70, Lund, Sweden, and Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. markus.johnsson@camurus.ideon.se
Journal of the American Chemical Society
|January 27, 2005
概括
这项研究描述了使用二氧化酸乙醇胺 (DOPE) 和PEGylated glycerol monooleate (PEG660-GMO) 的立方液晶相系统. 该系统形成具有稳定的立方相结构的体粒子,即使在稀释条件下.
科学领域:
- 材料科学 材料科学 材料科学
- 生物物理学的生物物理.
- 物理化学 物理化学
背景情况:
- 基于脂的液晶相在各种应用中至关重要.
- 二氧化酸乙醇胺 (DOPE) 是形成这种阶段的常见脂.
- 稳定这些相位,特别是在合体形式中,仍然是一个挑战.
研究的目的:
- 描述一个新的立方体液晶相系统.
- 为了研究PEGylated糖单酸盐 (PEG(660) -GMO) 对基于DOPE的立方相的影响.
- 为了探索这个系统中的体颗粒的形成.
主要方法:
- 使用DOPE,PEG660-GMO和水制备系统.
- 在不同度下进行相位行为分析.
- 立方相结构和粒子形成的表征.
主要成果:
- 一个稳定的立方体液晶相是由DOPE/PEG(660) -GMO/水系统形成的.
- 立方相与水共存,在相位图的稀释区域.
- 该系统可以被分解成保留立方相结构的状颗粒.
结论:
- 添加PEG(660) - 转基因稳定了基于DOPE的立方体液晶相.
- 该系统提供了一种创建稳定立方相纳米粒子的方法.
- 建议在药物输送和材料科学方面有潜在的应用.
相关概念视频
Two Components: Liquid–Liquid Systems
A pressure-composition phase diagram explicitly describes the behavior of an ideal solution of two volatile liquids under varying pressures and compositions. A pressure-composition diagram has two main curves. The bubble point curve represents the plot of pressure versus liquid mole fraction. It indicates the pressure at which the first bubble of vapor forms from the liquid phase as the system pressure decreases.The dew point curve is the pressure versus vapor mole fraction. It indicates the...
Nonideal Two-Component Liquid Solutions
Nonideal liquid solutions, also known as real solutions, do not strictly follow Raoult's law. Raoult's law is a rule of thumb in physical chemistry. However, not all mixtures adhere to this law due to varying molecular interactions. For example, in an acetone/chloroform solution, the individual vapor pressures of the components are lower than expected, resulting in a total vapor pressure below that predicted by Raoult's law, causing a negative deviation.On the other hand, in an ethanol/water...
Solid–Solid Solutions
The temperature-composition phase diagram of two solids, A and B, which are immiscible in the solid phase but form miscible liquids, shows that when the temperature is low, these two exist as separate, pure solids (A and B). As the temperature increases, they transition into a single-phase liquid solution where A and B coexist. Moving from point a1 to a2 in the phase diagram, the composition changes such that solid B begins to separate from the solution, enriching the remaining liquid with A.
Phase Diagrams of Ternary Systems
Consider a ternary system, which is composed of three components: water (W), ethanoic acid (E), and trichloromethane (T). Here, Ethanoic acid (E) is fully miscible with both water (W) and trichloromethane (T), meaning it can mix entirely with either of them. However, water and trichloromethane have partial miscibility, meaning they can only mix to a certain extent, beyond which two separate phases will form.The phase diagram of a ternary system is represented as an equilateral triangle, where...
Crystallographic Point Groups
Crystallographic point groups represent the various symmetry operations that can occur within crystals. They are unique in that at least one point will always remain unchanged during these actions. For instance, consider the triclinic system. This system, devoid of any axis or plane of symmetry, aligns with the C1 and Ci point groups.where Cᵢ is characterized solely by a center of inversion.Contrastingly, the monoclinic system introduces an element of symmetry. This system with one plane and...
Partial Fractions
A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...


