Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

In situ graphene-seq: spatial transcriptomics and chronic electrophysiological characterization of tissue microenvironments.

Nature communications·2026
Same author

Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart.

bioRxiv : the preprint server for biology·2026
Same author

Comprehensive guideline-directed medical therapy strategies on health status outcomes in patients with heart failure: the LAQUA-HF randomised clinical trial.

Heart (British Cardiac Society)·2026
Same author

Epicardial Complement C3 Activation in Neonatal Cardiac Regeneration.

Circulation·2026
Same author

Transcriptomic analysis of circulating extracellular vesicles during the perioperative period of Fontan and Glenn surgery.

NPJ cardiovascular health·2026
Same author

Leveraging the national cancer institute's collaborative efforts to understand the benefits and harms of cannabis use among individuals with cancer.

Journal of the National Cancer Institute·2026

相关实验视频

Updated: May 5, 2026

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering
11:32

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Published on: December 20, 2010

14.3K

可注射的自组合纳米纤维为内皮细胞创造了心脏内微环境.

Michael E Davis1, J P Michael Motion, Daria A Narmoneva

  • 1Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.

Circulation
|February 3, 2005
PubMed
概括
此摘要是机器生成的。

可注射的自组合在心脏中创建纳米纤维微环境,招募血管细胞并改善移植细胞的存活率以进行组织再生.

更多相关视频

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

8.2K
Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.7K

相关实验视频

Last Updated: May 5, 2026

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering
11:32

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Published on: December 20, 2010

14.3K
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

8.2K
Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.7K

科学领域:

  • 生物材料科学 生物材料科学
  • 心血管研究研究心血管研究
  • 再生医学是一种再生医学.

背景情况:

  • 提高移植细胞存活率和内源性前体支持是至关重要的.
  • 开发可注射的心肌微环境以促进血管化是一个关键目标.

研究的目的:

  • 研究自组装 (SAP) 在心肌内形成可注射纳米纤维微环境的潜力.
  • 评估这些微环境招募内皮细胞并支持血管化和细胞存活的能力.

主要方法:

  • 将自组装注入心肌,形成可检测的纳米纤维微环境.
  • 使用异构素和血小板-内皮细胞粘附分子-1 (PECAM-1) 染色对内皮细胞原生细胞的评估招募.
  • 评估了表达alpha-sarcomericactin和Nkx2.5.5的血管光滑肌细胞和心脏细胞的招募.
  • 在微环境中研究移植心肌细胞的存活率.

主要成果:

  • 自组装的基纳米纤维成功地形成并被检测到心肌内.
  • 这些微环境招募了内皮原生细胞和血管光滑肌细胞,形成了血管结构.
  • 心脏细胞和移植心肌细胞透并在微环境中存活,并观察到增强的存活率.

结论:

  • 自组装可以在心肌中创建功能性的纳米纤维微环境,促进血管细胞的招募.
  • 这些可注射的基纳米纤维为组织再生策略提供了一个多功能平台.
  • 这种方法显示了增强细胞存活率和促进心脏修复中的血管化方面的前景.