生物化学:皮罗洛基诺林是不是一种维生素?
Robert Rucker1, David Storms, Annemarie Sheets
1Department of Nutrition, College of Agriculture and Environmental Sciences, University of California, Davis, California 95616, USA. rbrucker@ucdavis.edu
皮罗洛基诺林 (PQQ) 被提出作为一种新的维生素. 然而,这项研究没有发现PQQ缺乏对动物氨酸代谢指标的影响,质疑其维生素状况.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 代谢研究研究 代谢研究
背景情况:
- 卡萨哈拉和卡托提出了类 (PQQ) 作为一种新型维生素.
- 他们的结论是基于在缺乏PQQ的动物中观察到的素代谢缺陷.
研究的目的:
- 复制那些将PQQ缺乏与lysine代谢缺陷联系在一起的发现.
- 批判性地评估PQQ.提议的维生素状态.
主要方法:
- 评估阿尔法-氨基酸-三角半化物 (AAS) 脱酶在肝脏中的活性.
- 测量氨酸 (AAA) 的血水平.
- 在补充PQQ的动物和缺乏PQQ的动物中比较这些指标.
主要成果:
- 没有观察到肝脏AAS脱酶活性的显著变化.
- 血AAA水平仍然不受饮食PQQ状态的影响.
- 这些发现与最初关于氨酸代谢中断的说法相矛盾.
结论:
- 该研究的结果不支持将PQQ确定为一种必需的维生素.
- 在哺乳动物氨酸代谢中PQQ的拟议作用需要进一步研究.
- 根据目前的证据,将PQQ归类为维生素是有问题的.
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