低血腺素水平预测冠状动脉化的进展
David M Maahs1, Lorraine G Ogden, Gregory L Kinney
1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA. David.Maahs@uchsc.edu
Circulation
|February 9, 2005
概括
低阿迪波涅丁水平预测冠状动脉化在1型糖尿病和非糖尿病患者中的进展. 这种关联与其他心血管风险因素保持独立,突出显示了皮菌素.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 在男性,晚期冠状动脉疾病,肥胖和2型糖尿病中,循环皮素的水平较低.
- 低平素在动脉样硬化发展中独立于危险因素的预测作用尚不清楚.
研究的目的:
- 为了调查低平素水平是否预测冠状动脉化 (CAC) 的进展.
- 评估这种关联在1型糖尿病患者和非糖尿病患者中.
主要方法:
- 一项嵌套病例对照研究分析了101例具有显著CAC进展的病例和205例对照的血腺素水平.
- 条件后勤回归模型根据基线CAC量和其他预测指标进行调整.
- 分析包括19-59岁的1型糖尿病患者和非糖尿病患者.
主要成果:
- 在糖尿病患者 (OR,0.47) 和非糖尿病患者 (OR,0.15) 中,阿迪波涅丁水平与CAC进展相反相关.
- 在调整了额外的心血管风险因素后,这种关联仍然存在.
- 在所有参与者 (P<0.001) 中都观察到CAC在亚迪波涅丁四分位数中的进展趋势具有统计学意义 (P<0.001).
结论:
- 低血腺素水平与1型糖尿病和非糖尿病个体的CAC进展有关.
- 这种关联与其他心血管风险因素独立.
- 皮菌素可以作为动脉样硬化进展的独立预测剂.
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