慢性静态不耐受性中神经循环异常
David S Goldstein1, Basil Eldadah, Courtney Holmes
1Clinical Neurocardiology Section, NINDS, National Institutes of Health, Bethesda, Md, USA. goldsteind@ninds.nih.gov
Circulation
|February 9, 2005
概括
患有姿势性心跳动综合征 (POTS) 的患者在休息时表现出心率增加和交感神经系统活动. 那些患有神经心脏性 (NCS) 的人表现出前臂血管收缩,但没有交感激活.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统研究 自主神经系统研究
- 临床生理学 临床生理学
背景情况:
- 慢性静止不耐症 (COI) 影响着姿势性心跳动综合征 (POTS) 的患者,有些患者患有神经心脏性 (NCS).
- 在COI患者的仰卧休息期间调查神经循环异常对于了解这些疾病至关重要.
研究的目的:
- 为了确定COI,POTS或NCS患者在卧底休息期间是否有明显的神经循环异常.
- 为了比较POTS,NCS和健康个体之间的卧式血动力学和神经激素配置.
主要方法:
- 患有COI (POTS或NCS) 的成年患者和健康的志愿者接受了血甲醇胺和前臂血动力学的测量.
- 两组之间的心率,动脉中上腺素和上腺素水平的平均值,以及前臂血管抵抗的比较.
主要成果:
- 与NCS和对照组相比,POTS组表现出明显更快的静止心率.
- POTS患者的血诺上腺素和上腺素水平高于NCS和对照组.
- 与POTS组相比,NCS患者在卧底休息期间表现出较高的前臂血管抵抗力.
结论:
- 静止性心力衰竭综合征 (POTS) 的特征是心率和交感神经系统和上腺外流的休息心率增加.
- 增加的交感外流可能导致在POTS中观察到的特征性心力衰竭.
- 神经心脏性 (NCS) 涉及休息时前臂血管收缩,没有交感神经或上腺激活的证据.
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