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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

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相关实验视频

Updated: Jul 6, 2026

Retroviral Transduction of T-cell Receptors in Mouse T-cells
10:14

Retroviral Transduction of T-cell Receptors in Mouse T-cells

Published on: October 22, 2010

收费类受体3促进对病毒感染细胞的交叉启动.

Oliver Schulz1, Sandra S Diebold, Margaret Chen

  • 1Immunobiology Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Nature
|February 16, 2005
PubMed
概括

病毒感染细胞中的双链RNA (dsRNA) 通过收费类受体3 (TLR3) 激活树突细胞,促进细胞毒性T细胞 (CTL) 交叉化. 这种TLR3依赖性途径在病毒感染期间增强了对细胞关联抗原的CTL反应.

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10:14

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Published on: October 22, 2010

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 病毒学 病毒学

背景情况:

  • 细胞关联抗原的交叉呈现对于CD8+ T细胞反应至关重要.
  • 树突细胞是交叉呈现中的关键抗原呈现细胞 (APC).
  • 确定T细胞交叉原始化与交叉耐受性的信号仍然不清楚.

研究的目的:

  • 阐明在病毒感染期间促进细胞毒性T细胞 (CTL) 交叉引发的机制.
  • 识别指示抗原呈现是否导致CTL激活或非激活的信号.
  • 研究双链RNA (dsRNA) 和通用类受体3 (TLR3) 在这个过程中的作用.

主要方法:

  • 通过感染细胞的dRNA激活小鼠CD8alpha+树突细胞.
  • 通过细胞和TLR3信号的树突细胞激活的评估.
  • 使用病毒感染细胞或合成dsRNA评估CTL交叉原始化的免疫研究.

主要成果:

  • 病毒感染的细胞中的dsRNA,但不是未感染的细胞,激活树突细胞.
  • 树突细胞的激活需要细胞和信号通过TLR3.
  • 用受感染细胞或dSRNA免疫显著增加CTL交叉原始化.
  • 这种交叉启动在很大程度上取决于 APC 的 TLR3 表达.

结论:

  • 通过dsRNA激活TLR3,促进了对细胞关联抗原的CTL交叉启动.
  • 这种机制对于对未直接感染树突细胞的病毒进行有效的CTL反应至关重要.
  • TLR3信号提供了病毒感染检测和适应性抗病毒免疫之间的关键联系.