患有性高血压的老年狗中心室结构和功能:实验性透心性心力衰竭模型
Vijaya K Munagala1, Chari Y T Hart, John C Burnett
1Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, Minn 55905, USA.
Circulation
|February 23, 2005
概括
在老年高血压犬中,扩张性心力衰竭 (DHF) 的新型大型动物模型显示,放松功能受损,硬度增加. 这种模型有助于理解DHF的病理生理学,显示高血压会导致缩,纤维化和心室功能的改变.
科学领域:
- 心血管生理学心血管生理学
- 疾病的动物模型.
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 扩张性心力衰竭 (DHF),以保存的喷射分数为特征,在老年高血压患者中很常见.
- 在DHF中改变腹腔功能的确切机制仍在争论中.
- 需要一个临床相关的大型动物模型来研究DHF病理生理学.
研究的目的:
- 开发和描述大动物模型的DHF.
- 为了阐明慢性高血压下老化心脏的结构和功能变化.
主要方法:
- 老狗接受脏包裹以诱导慢性高血压,创建一个实验性DHF (ExDHF) 组.
- 评估了心室结构和功能,并与年轻和老年对照组进行了比较.
- 关键参数包括左心室 (LV) 体积,质量,纤维化,放松 (tau),透析硬度和动脉硬度.
主要成果:
- 在ExDHF组表现出正常的LV体积,增加的LV质量和心肌纤维化.
- 与对照犬相比,ExDHF犬的LV放松显著受损.
- 在ExDHF狗中观察到LV缩和动脉硬度增加,而腹筋硬度系数保持不变.
结论:
- 年龄较大的高血压犬会发展出 LV 缩和纤维化,放松功能受损,模仿人类的 DHF.
- 增加 LV 缩和动脉硬性可能会使放松恶化,并在高血压期间增加填充压力.
- 这种大型动物模型为DHF的发病过程提供了有价值的见解.
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