不被激活基的有氧氧化氨基化,由催化
Jodie L Brice1, Jenna E Harang, Vitaliy I Timokhin
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.
Journal of the American Chemical Society
|March 3, 2005
概括
研究人员开发了第一个催化氧化氨基化对未被激活的烯的氧化氨基化. 这些反应不需要共催化剂,并且使用直接的二氧化物合催化剂周转,表明存在 cis-aminopalladation 机制.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
背景情况:
- 催化反应在有机合成中至关重要.
- 奥莱芬的氧化氨基化是一种有价值的转化,用于创建C-N键.
- 未激活的烯酸是一种重要的合成挑战.
研究的目的:
- 报告第一个成功的催化氧化氨基化未激活的烯酸.
- 为了建立直接的二氧化碳合催化剂周转率条件,没有共催化剂.
主要方法:
- 利用催化剂进行氧化氨基化.
- 直接使用二氧化物作为氧化剂.
- 使用诺波伦烯和其他循环基的研究反应.
- 在无共催化剂条件下进行的反应.
主要成果:
- 取得了第一个未被激活的烯酸的催化氧化氨基化的例子.
- 通过直接使用二氧化证明了成功的催化剂周转.
- 识别了与cis-aminopalladation机制相一致的反应产物.
结论:
- 无催化剂,与氧气合的催化剂可使具有挑战性的基质得到氧化氨化.
- 观察到的产物支持这些新型反应中的cis-aminopalladation路径.
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