冠状动脉化的种族差异:动脉样硬化多民族研究 (MESA)
Diane E Bild1, Robert Detrano, Do Peterson
1Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md, USA. bildd@nhlbi.nih.gov
Circulation
|March 17, 2005
概括
冠状动脉化患病率和数量在美国各族群之间有很大差异,即使考虑到风险因素. 需要进一步的研究来了解动脉样硬化的这些种族差异.
科学领域:
- 心血管疾病流行病学
- 动脉样硬化的研究研究.
- 医学成像在心脏病学中的医学成像.
背景情况:
- 冠状动脉化是冠状动脉样硬化的关键指标.
- 以前的研究表明,与黑人相比,美国白人冠状动脉化程度更高.
- 缺乏大规模的人口研究,比较不同美国族群的冠状动脉化.
研究的目的:
- 为了比较美国主要族群中冠状动脉化的流行率和数量.
- 调查传统的心血管风险因素是否解释冠状动脉化的种族差异.
- 建立未来关于动脉样硬化的种族差异研究的基准.
主要方法:
- 使用计算机断层扫描 (CT) 来测量冠状动脉化 (阿加斯顿分数).
- 在多民族动脉样硬化研究 (MESA) 中分析了6814名参与者 (45-84岁) 的数据.
- 包括白人,黑人,西班牙裔和中国男性和女性,没有先前的临床心血管疾病.
主要成果:
- 冠状动脉化的患病率在白人男性 (70.4%) 和女性 (44.6%) 中最高.
- 调整后的分析显示,与白人相比,黑人,西班牙裔和中国人的冠状动脉化的相对风险较低.
- 白人表现出最多的冠状动脉化,其次是中国人,西班牙裔和黑人.
结论:
- 在冠状动脉化的存在和程度上存在显著的种族差异.
- 这些差异并不能完全由常见的冠状动脉风险因素来解释.
- 需要进一步研究冠状动脉的潜在机制和跨种族群体的预测价值.
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