烟草马赛克病毒的双表面修饰
Tara L Schlick1, Zhebo Ding, Ernest W Kovacs
1Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.
Journal of the American Chemical Society
|March 18, 2005
概括
研究人员开发了两种方法来修改烟草马赛克病毒 (TMV) 体,从而实现了新的纳米级材料应用. 这些策略允许外部或内部表面的功能化,用于各种用途.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 病毒学 病毒学
背景情况:
- 烟草马赛克病毒 (TMV) 体为纳米级材料开发提供了一个独特,坚固,管状的支架.
- 扩大TMV体的功能能力对于材料科学和纳米技术的新型应用至关重要.
研究的目的:
- 开发和演示用于修改TMV体外表面和内部表面的合成策略.
- 为了使各种功能组件能够连接到TMV的脚手架上.
- 展示开发的功能化方法的直角性.
主要方法:
- 通过二氧化联接/氧化物形成序列实现外部功能化,实现高表面密度 (>2000个副本/体).
- 内部功能化使用碳胺合物合物将氨基连接到谷氨酸残留物.
- 使用生物素,染色体,皇冠和聚乙烯糖醇 (PEG) 聚合物表现功能化.
主要成果:
- 成功地安装了2000多个功能单元,每个功能单元的外.
- 修改TMV囊的内腔.
- 通过PEGylation制备有机溶解的TMV棒.
- 展示直角函数的功能,允许在同一个面的内部和外部表面上进行明显的修改.
结论:
- 两个独特而高效的合成策略使TMV囊的多功能功能化成为可能.
- 这些方法显著扩大了基于TMV的纳米材料的潜在应用.
- 反应的直角性允许复杂的,多功能化的TMV纳米结构.
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