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Updated: Jul 7, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

分子决定因素和物种特异性RNA编辑的指导演变

Robert A Reenan1

  • 1Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA. rreenan@neuron.uchc.edu

Nature
|March 18, 2005
PubMed
概括

在Synaptotagmin I (sytI) 中的腺酸到酶酸RNA编辑显示了显著的物种特异性变异. 复杂的内基RNA结构,包括一个新的伪结,在六足动物进化过程中决定了这些编辑模式.

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RNA Splicing01:32

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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