Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Management of Temporal Bone Fractures: Optimizing the Role of Otolaryngology Consultation.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Updates on the Evaluation and Treatment of Orbital Fractures.

Facial plastic surgery clinics of North America·2025
Same author

A Taxonomic Revision of the Genus <i>Cleopus</i> Dejean, 1821 (Coleoptera, Curculionidae), with Descriptions of 13 New Species.

Insects·2024
Same author

Disease and toxicity outcomes for a modern cohort of patients with squamous cell carcinoma of cutaneous origin involving the parotid gland: Comparison of volumetric modulated arc therapy and pencil beam scanning proton therapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2024
Same author

A TAXONOMIC REVISION OF THE AFROTROPICAL SPECIES OF THE WEEVIL GENUS CIONUS (COLEOPTERA: CURCULIONIDAE).

Zootaxa·2023
Same author

A Taxonomic Revision of the Genus <i>Cionus</i> (Coleoptera, Curculionidae) from the Oriental Region.

Insects·2023

相关实验视频

Updated: Jun 23, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

静脉注射levosimendan对人类冠状动脉血管运动调节,左心室壁应力和心肌氧气吸收的影响.

Andrew D Michaels1, Barry McKeown, Michael Kostal

  • 1Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, San Francisco 94143-0124, USA. andrewm@medicine.ucsf.edu

Circulation
|March 23, 2005
PubMed
概括

静脉输入的levosimendan扩大冠状动脉,增加血液流动并改善心脏效率. 这项研究研究了它对心力衰竭患者冠状动脉血管和心肌氧气吸收的影响.

更多相关视频

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

相关实验视频

Last Updated: Jun 23, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

科学领域:

  • 心脏病学 心脏病学
  • 药理学 药理学是指药理学的学科.
  • 生理学 生理学 生理学

背景情况:

  • 莱沃西门丹是一种用于减补心力衰竭的内扩剂.
  • 它对人类冠状动脉血管,心肌壁压力和氧气吸收的影响需要进一步研究.

研究的目的:

  • 为了研究静脉注射levosimendan对人类冠状动脉血管系统的影响.
  • 评估其对心肌壁应力和氧气吸收的影响.

主要方法:

  • 十名成年患者接受了心脏导管治疗.
  • 在levosimendan输注前后测量了冠状动脉血流,心肌氧吸收和血液动力学.
  • 心声扫描评估了左心室功能和壁压力.

主要成果:

  • 莱沃西门丹增加了心脏输出量和射出率,同时降低了肺毛细血管压和全身血管阻力.
  • 发生了显著的冠状动脉血管扩张,直径,速度和血液流量增加,尽管冠状动脉阻力下降.
  • 心肌的氧气提取减少,表明效率有所提高.

结论:

  • 静脉输入的levosimendan作为冠状动脉血管扩张剂,增加冠状动脉血流.
  • 它可以改善左心室缩功能和心肌效率.
  • 莱沃西门丹对冠状动脉血管和心脏表现有有益影响.