治疗真菌病的治疗方法
A Wong-Beringer1, R A Jacobs, B J Guglielmo
1Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0622.
JAMA
|May 27, 1992
概括
抗真菌膀灌,特别是安福特里辛B,显示出对无并发性真菌病的希望. 然而,不一致的研究设计限制了真菌性尿路感染的最终治疗建议.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 尿液中的真菌或真菌存在是一个越来越令人担忧的问题,特别是在医疗机构.
- 不复杂的真菌病缺乏明确的治疗指南,因为高质量的证据有限.
研究的目的:
- 审查和评估针对无并发性真菌病的抗真菌治疗方法.
- 确定有效的抗真菌剂,并评估风险因素对治疗结果的影响.
主要方法:
- 系统审查英语病例报告和研究 (1960-1991) 关于无并发性真菌病治疗.
- 对研究设计,定义,治疗方案,风险因素和患者随访的分析.
主要成果:
- 抗真菌药物的直接比较受到研究方法的异质性阻碍.
- 安福特素B膀灌似乎是最有效的;基托可纳最不有效.
- 诸如尿导管之类的诱导因素显著影响治疗失败.
结论:
- 目前的证据不足以推针对无并发性真菌病的特定治疗方案.
- 需要有前性,经过良好控制的研究来确定最佳的治疗策略.
- 症状病例需要治疗,但最好的方法仍未确定.
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