相关实验视频
Updated: Jul 5, 2026

09:36
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
在一系列桥接乳母体中,易于C-N裂变
Yao Lei1, Aaron D Wrobleski, Jennifer E Golden
1Department of Medicinal Chemistry, 1251 Wescoe Hall Drive, Room 4070, Malott Hall, University of Kansas, Lawrence, KS 66045-7582, USA.
Journal of the American Chemical Society
|March 31, 2005
概括
紧张的双环和三环胺对C-N键裂变具有很高的敏感性. 与H2/Pd ((OH) 2 ,MeI和DDQ的反应选择性地打破了最扭曲的C-N键,为反应机制提供了洞察力.
科学领域:
- 有机化学 有机化学
- 反应机制 反应机制
- 合成方法论 合成方法论
背景情况:
- 压力循环胺具有独特的化学特性.
- 对于合成应用来说,了解应力系统中的C-N键裂变至关重要.
- 之前的研究还没有完全探索这些特定的胺基结构的反应性.
研究的目的:
- 调查压力双和三环胺对C-N键裂变的敏感性.
- 识别促进容易C-N键裂变的试剂和条件.
- 探索这些裂变反应的区域选择性和潜在机制.
主要方法:
- 一系列应变的双环和三环胺的合成.
- 用催化化 (H2/Pd(OH) 处理胺基.
- 与甲基化物 (MeI) 和2,3-二-5,6-二-1,4-基 (DDQ) 的反应.
主要成果:
- 在测试条件下,胺对C-N键裂变表现出异常的敏感性.
- 随着H2/Pd(OH) 2 ,MeI和DDQ,裂变很容易发生.
- 反应具有高度区域选择性,有利于分裂最扭曲的C-N键.
结论:
- 张力胺基可以在胺基相邻的C-N键上选择性地分裂.
- 偏离平面性的程度决定了C-N键裂变的位置.
- 初步的机理学研究表明这些转变的具体途径.
相关概念视频
Phosphodiester Linkages
Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Gap Junctions
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
Peptide Bonds
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Overview of Cell-Matrix Interactions
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
The Mammary Glands
The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...

