人类Mpp11 J蛋白:与核糖体结合的分子伴侣是无处不在的
Heather A Hundley1, William Walter, Shawn Bairstow
1Department of Biochemistry, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.
概括
与核糖体相关的分子伴侣,如人类的Mpp11,链接蛋白质翻译和折叠. 酵母Zuo的正方体Mpp11,与Hsp70的陪伴者合作,以协助新生的多链.
科学领域:
- 分子生物学分子生物学
- 蛋白质折叠过程中的蛋白质折叠
- 细胞机制 细胞机制
背景情况:
- 专门的分子陪伴者直接与微生物中的核糖体相互作用.
- 这些陪伴体结合了离开的多,将翻译和蛋白质折叠联系起来.
- 与核糖体相关的陪伴体对于细胞蛋白质平衡至关重要.
研究的目的:
- 为了研究核糖体中与核糖体相关的分子伴侣的进化保存.
- 为了表征酵母Zuo的人类正方形,命名为Mpp11.
- 为了了解Mpp11与Hsp70陪伴者的相互作用.
主要方法:
- 比较基因组学以确定酵母酵母的真核体正基因组 Zuo.
- 在酵母表达的人类Mpp11的功能分析.
- 生物化学测试用于研究伴侣相互作用.
主要成果:
- 在真核生物进化过程中,Mpp11,是酵母Zuo的人类正义体,一直保持着.
- 表达的Mpp11部分替代了酵母中的Zuo函数.
- 在酵母中,Mpp11与Ssa (酵母Hsc70同类) 合作.
结论:
- 与核糖体相关的分子伴侣在真核生物中被进化保存.
- Mpp11代表了甲基动物中保守的核糖体相关的陪伴者.
- Mpp11可能会将Hsc70招募到新生的多中,这些多会从甲基动物的核糖体中脱离.
相关概念视频
Noncovalent Attractions in Biomolecules
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Protein Complexes with Interchangeable Parts
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Sugars as Energy Storage Molecules
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
Protein Complexes with Interchangeable Parts
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Noncovalent Attractions in Biomolecules
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Sugars as Energy Storage Molecules
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...


