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Updated: Jul 12, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
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A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

Published on: January 29, 2017

长效注射纳尔特雷克松治疗酒精依赖的有效性和耐受性:一项随机对照试验

James C Garbutt1, Henry R Kranzler, Stephanie S O'Malley

  • 1Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599-7160, USA. jc_garbutt@med.unc.edu

JAMA
|April 7, 2005
PubMed
概括

长期作用的注射纳尔特雷克松有效地减少了六个月的酒精依赖患者的重度饮酒日数. 这种新的配方为治疗酒精依赖症的每日口服药物提供了一个耐受良好的替代品.

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...