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对MyD88-IRF-7信号的时空调节,用于强大的I型干扰素诱导

Kenya Honda1, Yusuke Ohba, Hideyuki Yanai

  • 1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Nature
|April 9, 2005
PubMed
概括

等离子体树突细胞通过Toll-like受体9 (TLR9) 和MyD88-IRF-7信号传导诱导I型干扰素 (IFN). 与传统的树突细胞不同,这些细胞中TLR9连接体的内体保留是强大的IFN诱导的关键.

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