西姆瓦斯塔丁在体内抑制了内毒素诱导的组织因子
Sabine Steiner1, Walter S Speidl, Johannes Pleiner
1Second Department of Medicine, Division of Angiology, Medical University of Vienna,Vienna, Austria.
Circulation
|April 13, 2005
概括
在内毒性病期间,西姆瓦斯塔丁可降低炎症和单细胞组织因子 (TF) 表达. 这种他类药物治疗对健康人群的血小板激活没有影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 类他类药物除了降脂之外,还具有抗炎性质.
- 实验室研究表明,他类药物抑制了脂聚糖 (LPS) 诱导的单细胞组织因子 (TF) 表达.
- 这项研究调查了在实验性内毒症中对炎症和血凝剂反应的他类药物的影响.
研究的目的:
- 评估simvastatin对LPS的炎症和血凝剂反应的体内影响.
- 评估simvastatin对单细胞TF表达和相关炎症标志物的影响.
- 为了确定simvastatin是否会在内毒性病期间影响血小板激活.
主要方法:
- 这是一项双盲,安慰剂控制的研究,涉及20名健康男性,随机分配给simvastatin或安慰剂4天.
- 静脉注射LPS后进行血hsCRP,MCP-1,sCD40L,sCD40和F1.2.2.的测量.
- 通过全血流细胞计评估的单细胞TF表达和单细胞-血小板聚合物.
主要成果:
- 西姆瓦斯塔丁显著抑制了LPS诱导的hsCRP和MCP-1的增加.
- 在LPS挑战后,他类药物治疗减弱了单细胞TF表达的增加.
- 西姆瓦斯塔丁显著降低了内毒素诱导的前热血素碎片F1.2.2.的形成.
- 输入LPS并没有改变单细胞 - 血小板聚合物的形成或血sCD40/sCD40L水平.
结论:
- 辛巴斯塔丁在体内有效抑制对内毒素的炎症反应.
- 在实验性内毒症期间,西姆瓦斯塔丁减弱单细胞组织因子表达.
- 在这个模型中,静止剂的使用没有影响血小板激活.
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