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Updated: May 8, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 18, 2011

针对BRCA突变细胞中的DNA修复缺陷作为治疗策略

Hannah Farmer1, Nuala McCabe, Christopher J Lord

  • 1Cancer Research UK Gene Function and Regulation Group, London, UK.

Nature
|April 15, 2005
PubMed
概括

BRCA1或BRCA2基因功能障碍使癌细胞对PARP抑制剂敏感. 这是因为阻断PARP活性会阻止DNA修复,导致细胞死亡,并建议新的癌症治疗策略.

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