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Updated: Jan 7, 2026

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
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与ADP结合的阿波性蛋白酶激活因子1的结构

Stefan J Riedl1, Wenyu Li, Yang Chao

  • 1Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey 08544, USA.

Nature
|April 15, 2005
PubMed
概括

亡蛋白酶激活因子1 (Apaf-1) 蛋白质保持不活跃,直到它与ATP结合,形成激活caspase-9.9的复合体. 这项研究揭示了非活性Apaf-1的晶体结构,详细说明了ADP如何将其锁定在非功能状态中.

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