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Updated: Jul 9, 2026

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection
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IKKalpha限制了巨细胞NF-kappaB的激活,并有助于解决炎症

Toby Lawrence1, Magali Bebien, George Y Liu

  • 1Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, California 92093, USA. t.lawrence@imperial.ac.uk

Nature
|April 29, 2005
PubMed
概括

伊卡帕B激酶 (IKK) α子单元通过促进NF-kappaB的去除来抑制炎症. 这与IKKbeta形成鲜明对比,突出了IKK子单元在先天免疫中的对立作用.

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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NF-kB-dependent Signaling Pathway

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NF-κB-dependent Signaling Mechanism
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