相关实验视频
Updated: May 6, 2026

Programmed Electrical Stimulation in Mice
Published on: May 27, 2010
延长QRS持续时间与死亡的关联在一个临床试验中,用于鼻节功能障碍的心脏起器治疗
Michael O Sweeney1, Anne S Hellkamp, Kerry L Lee
1Cardiac Arrhythmia Service, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA. mosweeney@partners.org
延长的QRS持续时间 (QRSd) 预测了接受心脏起器的鼻节功能障碍患者的死亡. 较高的QRSd值与死亡风险增加有关,但与心力衰竭住院无关.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 医学预测 医学预测
背景情况:
- 延长的QRS持续时间 (QRSd) 是已知的预测因素死亡率和心力衰竭住院治疗心力衰竭患者.
- 在需要心脏起器治疗的鼻节功能障碍患者中,基线QRSd的预后意义仍然不清楚.
研究的目的:
- 调查基线QRS持续时间与死亡风险和心力衰竭住院的风险之间的关联,在接受心脏起器植入的鼻节功能障碍患者中.
主要方法:
- 从2010年MOST试验 (Mode Selection Trial) 患者的12导电心电图中分析了基线QRS持续时间.
- 这项研究是一项为期6年的随机试验,比较了双室与腹腔节奏在患有鼻节功能障碍的患者中.
- 用调整的考克斯比例危险模型来评估死亡和心力衰竭住院预测因素.
主要成果:
- 在23.4%的患者中观察到基线QRS持续时间>=120毫秒,并且与年龄较大,较低的射出分数,心肌病和先前心力衰竭有关.
- 基线QRS持续时间>=120毫秒独立预测死亡风险增加 (HR 1.35;95% CI 1.07-1.70;P=0.010),但不是心力衰竭住院治疗.
- 随着QRS持续时间从60到120毫秒 (P=0.002),死亡风险逐渐增加,在调整后,10毫秒的增加与1.14倍更高的危险比率 (95%CI1.05-1.23) 相联系.
结论:
- 在需要心脏起器治疗的鼻节功能障碍患者中,基线QRS持续时间>=120毫秒显著与死亡风险增加有关.
- 增加QRS持续时间是该患者群体死亡率的有价值的预后标志物.
更多相关视频
12:45Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
09:20Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
Published on: July 5, 2021
相关概念视频
Decreased pulse rate
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
Dysrhythmias III: Characteristics of Dysrhythmias
Dysrhythmias IV: Characteristics of Bradyarrhythmias
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias