从块共聚合物/表面活性剂复合物中稀释诱导的球体到囊泡的菌根体的形态转变
Zhijun Hu1, Alain M Jonas, Sunil K Varshney
1Unité de Chimie des Matériaux Inorganiques et Organiques (CMAT) and Research Center in Micro- and Nanoscopic Materials and Electronic Devices (CeRMiN), Université catholique de Louvain, Place Pasteur 1, 1348 Louvain-la-Neuve, Belgium,.
Journal of the American Chemical Society
|May 5, 2005
概括
用于分子封装的稳定囊泡是通过重组球形小粒形成的. 这种在中自组装的过程为药物输送应用提供了一种新方法.
科学领域:
- 聚合物科学 聚合物科学
- 材料化学 材料化学
- 纳米技术纳米技术
背景情况:
- 块共聚合物自组装成各种纳米结构.
- 聚乙烯-块-聚4-乙烯胺是一种多用途的块共聚合物.
- 表面活性剂在细胞和囊泡形成中起着至关重要的作用.
研究的目的:
- 为了研究聚合物微粒的形态转变.
- 探索用于自组装的块共聚物和表面活性剂的使用.
- 开发一种用于封装感兴趣的分子的方法.
主要方法:
- 混合聚乙烯-块-聚乙烯-双块共聚合物与化中的 perfluorinated 表面活性剂.
- 通过稀释诱导形态重组.
- 描述由此产生的纳米结构 (小和囊泡).
主要成果:
- 成功形成了转基因稳定的球形粒.
- 稀释诱导过渡到更稳定的囊泡.
- 囊泡形成是一种可控制的形态重组.
结论:
- 块共聚物与表面活性剂的自我组装可以导致囊泡形成.
- 这种形态过渡为分子封装提供了一条途径.
- 开发的系统显示了在药物输送和纳米技术中的应用潜力.
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