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相关概念视频

Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Tight Junctions01:29

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...

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相关实验视频

Updated: Jul 12, 2026

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology
09:03

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology

Published on: June 21, 2013

热封闭的脂质体是热封闭的

Wen-Hua Chen1, Steven L Regen

  • 1Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.

Journal of the American Chemical Society
|May 5, 2005
PubMed
概括

热封闭的脂质体 (TGL) 结合了形成孔隙的两体和对温度敏感的脂质体. 在41°C以上,TGL释放被困的溶液;在这个温度以下,释放量显著减少.

科学领域:

  • 生物材料科学 生物材料科学
  • 药物输送系统 药物输送系统
  • 纳米技术 纳米技术

背景情况:

  • 由1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) 组成的脂质体在41°C时表现出相变.
  • 形成毛孔的两生物可以破坏脂质二层的稳定.
  • 控制释放系统对于向治疗至关重要.

研究的目的:

  • 开发和描述热封闭脂质体 (TGLs).
  • 为了研究从TGL中依赖温度释放的水性溶液.
  • 探索TGLs在治疗剂传递方面的潜力.

主要方法:

  • 从氨酸,胆酸和精氨酸中合成形成孔隙的两 (化合物1).
  • 使用DPPC制备脂质体.
  • 将化合物1纳入DPPC脂质体,以形成TGLs.
  • 在不同温度下测量来自TGL的碳氧光素流量.

主要成果:

  • 化合物1有效地在DPPC脂质体中形成毛孔,超过41°C的相位过渡温度.
  • 在41°C以上观察到显著的碳氧化流.
  • 流量率大幅降低至低于41°C,表明温度控制的释放.

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

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Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

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Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology
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Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology

Published on: June 21, 2013

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

结论:

  • TGL 显示可调节的,取决于温度的溶液释放.
  • 开发的TGL系统显示出对受控和向药物输送应用的前景.
  • 需要进一步的研究来探索TGLs的体内疗效和治疗潜力.