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相关概念视频

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...

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相关实验视频

Updated: May 7, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

表观性和平衡的多态性影响复杂的特征变异.

Juergen Kroymann1, Thomas Mitchell-Olds

  • 1Max Planck Institute for Chemical Ecology, Department of Genetics & Evolution, Hans-Knoell-Str. 8, D-07745 Jena, Germany. kroymann@ice.mpg.de

Nature
|May 6, 2005
PubMed
概括

小效应量化特征位点 (QTL) 对复杂的特征有显著的贡献. 这项研究在一个小的Arabidopsis thaliana间隔中发现了两个增长率QTL,揭示了复杂的遗传相互作用和潜在的平衡选择.

科学领域:

  • 植物遗传学 植物遗传学
  • 定量性质特征遗传学 遗传学
  • 人口遗传学 人口遗传学

背景情况:

  • 复杂的特征受到众多基因 (多基因) 的影响,但小效应的定量特征位置 (QTL) 仍未得到充分研究.
  • 了解复杂特征的遗传结构对于农业和医学等领域至关重要.

研究的目的:

  • 为了研究Arabidopsis thaliana在一个小的染色体间隔内的遗传复杂性.
  • 识别和描述增长速度的定量特征位置 (QTL) 和它们的相互作用.

主要方法:

  • 在Arabidopsis thaliana中剖析一个百分之一的染色体间隔.
  • 在不同加入的间隔内分析历史序列多态性.
  • 识别QTL增长速度和评估它们的表皮性相互作用.

主要成果:

  • 在210基基基底区域内发现了两个增长速度的QTL,这表明在一个小的基因组区域中具有高度的遗传复杂性.
  • 两种QTL都表现出表达性,这意味着它们的影响取决于遗传背景.
  • 一个QTL映射到单个基因,显示出平衡选择的核酸签名,具有上下文依赖的表型效应.

结论:

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A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
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A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

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Published on: November 3, 2010

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07:55

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  • 这些发现表明,定量特征变异的高度多基因架构,超过了以前的文档.
  • 非中性表观多态可能在复杂特征的遗传变异中发挥重要作用.
  • 这项研究强调了在理解复杂特征时考虑小效应的QTL和基因环境相互作用的重要性.