通过UV-DDB-ubiquitin结合酶复合体介导的XPC蛋白的紫外线诱导的无处不在

Kaoru Sugasawa1, Yuki Okuda, Masafumi Saijo

  • 1Cellular Physiology Laboratory, RIKEN Discovery Research Institute, Japan Science and Technology Agency, Wako, Saitama 351-0198, Japan. sugasawa@riken.jp

Cell
|May 11, 2005
PubMed
概括

在DNA修复过程中,Xeroderma pigmentosum群C (XPC) 蛋白质复合物的ubiquitylation至关重要. 这一过程依赖于紫外线损伤的DNA结合蛋白 (UV-DDB),促进了用于核酸切割修复 (NER) 的紫外线诱导的DNA损伤的转移.

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