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相关概念视频

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.

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相关实验视频

口服维生素D3和用于老年人中低创伤骨折的二次预防 (随机评估或维生素D,RECORD):一个随机的安慰剂受控试验.

A M Grant1, A Avenell, M K Campbell

  • 1Health Services Research Unit, University of Aberdeen, UK.

Lancet (London, England)
|May 12, 2005
PubMed
概括

常规的维生素D3和补充剂并不能防止移动老年人的二次骨折. 这项研究发现,补充剂组和安慰剂组之间的骨折率没有显著差异.

相关实验视频

科学领域:

  • 老年学是指老年学的学科.
  • 骨健康 骨健康 骨健康
  • 营养流行病学 营养流行病学

背景情况:

  • 患有先前骨折的老年人面临后续骨折的高风险.
  • 维生素D和补充剂通常被推用于预防骨折在这个人口.
  • 维生素D3和的有效性,单独或结合,预防二次骨折需要彻底调查.

研究的目的:

  • 评估口服维生素D3和补充剂在预防老年人二次骨折方面的有效性.
  • 为了比较单独的维生素D3,单独的和它们的组合与安慰剂的影响.

主要方法:

  • 一个因子设计的随机受控试验,涉及5292名70岁及以上的参与者.
  • 参与者被随机分配每天接受口服维生素D3 (800 IU), (1000 mg),两者,或安慰剂.
  • 随访时间为24至62个月,主要结果是新的低能量的骨折.

主要成果:

  • 在和非组 (HR 0.94),维生素D3和非维生素D3组 (HR 1.02) 或组合和安慰剂组 (相互作用HR 1.01) 之间没有观察到新的低创伤骨折发生率的显著差异.
  • 所有新骨折的发生率,放射性确认的骨折,关节骨折,死亡率,跌倒率和生活质量在各组之间没有显著差异.
  • 人们注意到对片的遵守程度较低,部分原因是胃肠道症状,尽管严重的不良事件很少发生,并且均分布.

结论:

  • 研究结果不支持常规使用口服维生素D3和补充剂来预防移动老年人进一步骨折.
  • 目前的证据没有证实这些补充剂在这个人群中广泛推用于预防二次骨折.