相关实验视频
在活跃的壮病中,用索马托斯塔丁类型的联合治疗和每周服用佩格维索曼特
J Feenstra1, W W de Herder, S M T H ten Have
1Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Lancet (London, England)
|May 12, 2005
概括
每月使用长效索马托他类药物与每周使用佩格维索曼特相结合,可有效地将胰岛素类生长因子I (IGF-I) 水平正常化. 这种方法提供了一个潜在的成本效益的治疗选择.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 巨症的特点是生长激素的过度产生,导致胰岛素类生长因子I (IGF-I) 水平升高.
- 佩格维索曼特单一治疗使IGF-I正常化,但与高成本有关.
- 目前的治疗策略旨在使IGF-I正常化并管理疾病并发症.
研究的目的:
- 为了评估结合疗法对壮症的疗效.
- 评估每月服用长效索马托斯塔丁类同类药物和每周服用佩格维索曼的组合.
- 为了确定Pegvisomant在组合治疗中的最佳剂量方案.
主要方法:
- 一项为期42周的剂量确定研究,涉及26名患有活跃巨症的患者.
- 患者每月接受长期起作用的索马托斯塔丁类似物和每周接受佩格维索曼特.
- 每周增加Pegvisomant剂量,直到达到IGF-I正常化或最高达到80mg/周.
主要成果:
- 完成42周的95%的患者 (18/19) 达到正常IGF-I度.
- 每周Pegvisomant的有效剂量中位数为60毫克 (范围为40-80毫克).
- 没有观察到下垂体瘤的生长;38%的患者出现轻微的肝酶升高.
结论:
- 联合治疗每月服用索马托斯塔丁类型药物和每周服用佩格维索曼特,对壮症治疗有效.
- 这种方案可以改善患者的服从性,并显著降低治疗成本.
- 需要进一步的研究来证实长期的安全性和成本效益.
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