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通过组织多普勒成像对小鼠的区域性心肌功能进行定量评估:与血液动力学和声微量学进行比较

Igal A Sebag¹, Mark D Handschumacher, Fumito Ichinose

¹Cardiac Ultrasound Laboratory in the Cardiology Division of the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mas 02114, USA.

|May 18, 2005

概括

组织多普勒成像 (TDI) 在小鼠中成功测量了心肌速度和应变率 (SR),提供了对左心室 (LV) 功能的敏感,非侵入性评估. 这些指数准确地反映了 LV 缩功能的变化,甚至在其他措施显而易见之前.

科学领域:

心血管成像 - 心血管成像
心声回声扫描 (Echocardiography) 是一种心声回声扫描.
心肌机械学心肌机械学

背景情况:

组织多普勒成像 (TDI) 是一种回声心脏成像技术,用于评估区域性心肌功能.
在小鼠中量化心肌速度和应变率 (SR) 对于在临床前模型中研究左心室 (LV) 功能至关重要.

研究的目的:

为了确定TDI是否可以在小鼠中获得心肌速度和SR.
评估TDI指数在量化LV缩功能的变化中的准确性.

主要方法:

在小鼠中进行TDI以测量内心和心表缩速度和SR.
将TDI指数与侵入性测量 (dP/dt{max},声微米速度) 进行比较,并在内毒素挑战后进行序列测量.

主要成果:

在小鼠中,TDI可靠地获得了心肌速度和SR.
随着多布他胺和埃斯莫洛尔的使用,TDI指数表现出显著的变化,与dP/dt{max}有很强的相关性.
在内毒素挑战后,TDI检测到功能变化比像分数缩短等传统措施更早.

结论:

TDI是一种可行的非侵入性方法,用于测量小鼠的心肌速度和SR.
在小鼠模型中,TDI指数作为评估全球和区域LV功能的敏感标记.

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