听觉皮层持续发射,由喜欢的刺激引起
Xiaoqin Wang1, Thomas Lu, Ross K Snider
1Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. xwang@bme.jhu.edu
Nature
|May 20, 2005
概括
醒着的海的听觉皮层神经元持续向喜欢的声音发射,这与先前在麻醉动物中发现的不同. 这种持续的神经活动,特别是在A1区域,表明在处理持续的声学信息方面发挥了动态作用.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
背景情况:
- 听觉皮层中的神经元通常对声音表现出暂时的反应.
- 这挑战了人们对听觉皮层如何编码连续声信号的理解.
研究的目的:
- 为了研究听觉皮层神经元在清醒,行为灵长类动物的发射模式.
- 为了确定持续的神经反应是否发生在听觉皮层.
主要方法:
- 醒着的子的听觉皮层 (主要A1和侧带) 的单个神经元的电生理记录.
- 通过喜欢和不喜欢的声学刺激进行刺激.
主要成果:
- 醒着的大海的神经元表现出持续的发射模式,以首选的听觉刺激.
- 对非首选刺激的反应变得暂时.
- 在神经元群体和时间之间对声音的选择性表示.
结论:
- 听力皮层神经元可以持续发射,特别是对喜欢的刺激.
- 这种持续的活动与麻醉动物观察到的短暂反应形成鲜明对比.
- 研究结果表明,听觉皮层在编码正在进行的声音方面发挥了更为动态的作用.
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相关概念视频
Hearing
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Hair Cells
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
Motor and Sensory Areas of the Cortex
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Auditory Pathway
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
