乳腺癌诊断后的身体活动和生存率
Michelle D Holmes1, Wendy Y Chen, Diane Feskanich
1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA. michelle.holmes@channing.harvard.edu
JAMA
|May 26, 2005
概括
乳腺癌诊断后进行定期体育活动显著降低了死亡风险. 满足体育活动指南的女性可能会提高生存率,特别是那些有激素反应性瘤的女性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 身体活动与降低乳腺癌发病率有关.
- 它对诊断后复发和生存的影响尚不清楚.
研究的目的:
- 研究身体活动水平与乳腺癌死亡率之间的关联.
- 为了确定诊断后的身体活动是否会影响生存结果.
主要方法:
- 对2987名被诊断为I-III期乳腺癌的护士进行前性观察性研究.
- 随访直到死亡或2002年6月,评估身体活动 (MET-小时/周) 的死亡风险.
主要成果:
- 较高的体力活动 (≥9MET小时/周) 与乳腺癌死亡风险降低相关 (RR=0.50).
- 在患有激素反应性瘤的妇女中观察到显著的益处 (RR=0.50).
- 对于活跃女性,10年后的绝对死亡风险降低约6% (≥9MET小时/周).
结论:
- 诊断后的身体活动可能会降低乳腺癌死亡风险.
- 观察到的最佳益处是每周步行3-5小时;更强的强度显示收益下降.
- 坚持身体活动建议可以提高乳腺癌患者的生存率.
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