心上冠状动脉血管树的基本结构-功能关系. 对于扩散性冠状动脉疾病的定量冠状动脉谱的基础
C Seiler1, R L Kirkeeide, K L Gould
1University of Texas Medical School, Houston 77030.
Circulation
|June 1, 1992
概括
定量冠状动脉造影现在可以通过将冠状动脉大小与心肌偏距床大小相关联来量化扩散冠状动脉疾病. 这种方法揭示了在患有扩散性疾病的患者中大大低估了动脉大小.
科学领域:
- 心血管成像 - 心血管成像
- 生物医学工程 生物医学工程
- 定量解剖学 定量解剖学
背景情况:
- 定量冠状动脉造影 (QCA) 是为局部狭窄性病变建立的.
- 目前,QCA无法评估扩散性冠状动脉疾病,因为与心肌偏远质量相比,动脉的正常尺寸尚不清楚.
研究的目的:
- 建立一种使用临床冠状动脉图量化扩散性冠状动脉疾病的方法.
- 为了确定冠状动脉大小和偏心肌床大小之间的正常关系.
- 确定控制人类冠状动脉树结构的物理原理.
主要方法:
- 对12名健康人群和17名冠状动脉疾病患者的临床冠状动脉图进行分析.
- 定量冠状动脉造影以测量灯膜面积,远端分支长度和区域心肌质量.
- 观察到的血管几何与三个理论物理原理的比较.
主要成果:
- 在健康和疾病状态下,冠状动脉光膜面积和远端心肌质量/分支长度之间存在强烈的相关性.
- 与对照人群相比,患有扩散性疾病的冠状动脉与远端心肌床大小相比,其光面积比对照人群小30-50%.
- 冠状动脉树结构与最小能量损失和适应性剪切应力原则保持一致,而不是恒定流速.
结论:
- 已确定的相关性为从临床动脉图中量化扩散性冠状动脉疾病提供了基础.
- 这种方法可以客观地评估扩散性动脉样硬化,提高诊断能力.
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