在冠状动脉狭窄期间,冠状动脉内甘的作用对相位模式和冠状动脉狭窄期间的流动的横向分布的影响
M Goto1, A E Flynn, J W Doucette
1Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki, Japan.
Circulation
|June 1, 1992
概括
冠状腺内糖可能无法缓解心痛,原因是缩逆流量增加,这会损害心下血管血流,尽管心脏缺血心脏中心下血管流量增加.
科学领域:
- 心血管生理学心血管生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 酸甘油有效地缓解心肌缺血.
- 冠状腺内糖可能无法缓解心痛,并可能对心下内脏血流产生负面影响.
- 这些影响背后的机制需要研究.
研究的目的:
- 研究酸甘油对缺血性心脏冠状动脉循环的直接影响.
- 为了阐明酸甘和冠状动脉血流模式之间的关系.
主要方法:
- 使用80通道,20MHz脉冲多普勒超声波流量计来测量心脏内冠状动脉流量.
- 采用放射性微球来评估心肌外血流分布.
- 在麻醉的开胸狗中研究了诱导冠状动脉狭窄的效果.
主要成果:
- 尼糖的使用降低了静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉静脉
- 酸甘油增加了透缩前向流量,但显著增加了抽缩反向流量.
- 用酸甘增加了心下流量,而心下流量没有增加,导致心下和心下流量比率降低.
结论:
- 在冠状动脉内尼托格利后增加的缩逆流是关键因素.
- 这种增强的缩逆流与心下内脏血流无法改善密切相关.
- 这些发现表明,在某些缺血症条件下,尼甘的有效性有限的潜在机制.
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